Fluralaner CAS 864731-61-3

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Fluralaner (CAS 864731-61-3) is a systemically administered insecticide and acaricide belonging to the isoxazoline class. It is widely used in veterinary medicine for long-term control of fleas, ticks, and mites in companion animals and poultry.

A key differentiator of Fluralaner is its extended 12-week duration of efficacy following a single dose, significantly reducing dosing frequency compared to conventional monthly products. As a professional Fluralaner API manufacturer and supplier, we provide high-purity (≥99.0%) Fluralaner API with full GMP documentation to support the development of oral chewables, topical solutions, and injectable formulations.

Drug Class: Isoxazoline ectoparasiticide
Form: High-purity crystalline powder

How Fluralaner Works:

• Dual Chloride Channel Inhibition: Potent antagonist of ligand-gated chloride channels, targeting GABA-gated and L-glutamate-gated receptors in insects and arachnids
• High Receptor Selectivity: Strong affinity for arthropod receptors with minimal interaction with mammalian receptors, contributing to a wide safety margin
• Resistance Management: Maintains efficacy against parasite populations resistant to older classes such as organophosphates, pyrethroids, and fipronil

Veterinary Use

• Long-Lasting Protection: Up to 12 weeks of continuous flea and tick control after a single administration
• Broad Spectrum Activity: Effective against:
• Fleas (Ctenocephalides spp.)
• Ticks (Ixodes, Dermacentor, Rhipicephalus)
• Mites (Demodex, Sarcoptes)
• Flea Allergy Dermatitis (FAD): Supports treatment by eliminating the underlying flea infestation

Poultry Industry

Used in drinking-water formulations (in selected regions) for the control of red mite (Dermanyssus gallinae) in laying hens, improving animal welfare and productivity.

Fluralaner is generally well tolerated in animals when used at recommended doses. Most adverse events are mild and transient. The most commonly reported side effects include:

 

Gastrointestinal

• Vomiting
• Diarrhea
• Decreased appetite
• Drooling (hypersalivation), especially shortly after oral dosing

Neurological (Uncommon but Notable)

• Lethargy
• Tremors
• Ataxia (uncoordinated movement)
• Seizures (rare; reported mainly in animals with or without a prior seizure history, consistent with the isoxazoline class)

General / Other

• Pruritus or skin irritation (more often with topical formulations)
• Mild injection-site reactions (for injectable or experimental formulations)

 

Is Fluralaner Toxic to Dogs?

Fluralaner is generally safe and well tolerated in healthy dogs when administered at recommended doses. Safety studies show tolerance at up to 5× the maximum recommended dose, including in puppies from 8 weeks of age.
As with other isoxazolines, rare neurologic adverse events (e.g., tremors or seizures) have been reported, even in dogs without prior neurologic history. Veterinary supervision is advised.

Is Fluralaner the Same as Fipronil?

No. Although both target ectoparasites, they differ significantly:

 Fluralaner (Isoxazoline):

• Systemic (oral or topical)
• 12-week duration
• Novel binding site on GABA receptors

 Fipronil (Phenylpyrazole):

• Topical, skin-distributed
• Monthly application

Clinical studies demonstrate superior efficacy and longer duration for Fluralaner.

Is Fluralaner the Same as Ivermectin?

No. These compounds belong to different drug classes:

• Ivermectin: Macrocyclic lactone targeting internal parasites (e.g., heartworms)
• Fluralaner: Targets external parasites (fleas, ticks, mites)

They are often used concurrently without known adverse drug-drug interactions.

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