Omadacycline CAS 389139-89-3

Product Name Omadacycline Tosylate CAS Number 389139-89-3 Purity 99.0% Form Crystalline Powder

What Is Ozenoxacin?

Omadacycline Tosylate is a first-in-class aminomethylcycline antibiotic within the tetracycline family. It was rationally designed to overcome traditional tetracycline resistance mechanisms, including efflux pumps and ribosomal protection proteins, which limit the effectiveness of earlier agents.

As a qualified Omadacycline Tosylate API manufacturer and supplier, we provide high-purity (≥99.0%) Omadacycline suitable for the development of both oral and intravenous formulations, supported by complete regulatory documentation for global pharmaceutical markets.

Drug Class: Aminomethylcycline (3rd-generation tetracycline)
Dosage Form Compatibility: Oral tablets, IV formulations

What Is Omadacycline Used For?

Omadacycline exhibits broad-spectrum antibacterial activity against Gram-positive, Gram-negative, atypical, and anaerobic pathogens, including resistant strains.

Primary Clinical Indications

ABSSSI: Acute Bacterial Skin and Skin Structure Infections
CABP: Community-Acquired Bacterial Pneumonia
Resistant & Refractory Infections:

Growing research interest in Omadacycline for Mycobacterium abscessus due to promising in-vitro activity against non-tuberculous mycobacteria

These characteristics make Omadacycline a valuable option where older tetracyclines show reduced efficacy.

Mechanism of Action (MOA)

The Omadacycline mechanism of action involves inhibition of bacterial protein synthesis.

How Omadacycline Works:

Binds to the 30S ribosomal subunit
Blocks the attachment of aminoacyl-tRNA to the mRNA-ribosome complex
Effectively inhibits protein synthesis even in bacteria resistant to other tetracyclines

Its structural modifications allow Omadacycline to remain active where agents like Doxycycline fail, offering a significant advantage in resistant infections.

Common Omadacycline Side Effects

Clinical data indicates Omadacycline is generally well tolerated. Reported adverse events include:

Nausea and vomiting (especially during oral loading doses)
Infusion-site reactions (IV administration)
Transient elevations in liver enzymes (ALT/AST)

How Long Does Omadacycline Stay in the Body?

Elimination Half-Life: ~16–17 hours

Steady State: Achieved within 4–5 days of dosing

Clearance: Detectable for approximately 3–4 days after the last dose
This profile supports convenient once-daily dosing.

Omadacycline vs Doxycycline

From a formulation and procurement perspective, understanding the difference between Omadacycline and Doxycycline is critical.

Technical Comparison

Feature	Omadacycline (Nuzyra)	Doxycycline (Vibramycin)
Generation	3rd-generation aminomethylcycline	2nd-generation tetracycline
Resistance Profile	Overcomes efflux & ribosomal protection	High resistance rates globally
Primary Indications	ABSSSI, CABP, resistant infections	Acne, Lyme disease, STIs, malaria
Dosing Frequency	Once daily (after loading dose)	Typically twice daily (BID)
Oral Bioavailability	~35% (strict fasting required)	~90–100%
Half-Life	16–17 hours	18–22 hours
Common Side Effects	GI upset, IV site pain	Photosensitivity, esophageal irritation

Why Choose Us as Your Omadacycline Supplier?

Direct Manufacturer & Global Exporter

Consistent GMP Quality with batch-to-batch reliability

Regulatory Support for international registrations

Competitive Wholesale Pricing

Secure, Long-Term Supply Partnerships

Message us to get your personalized quotation within 24 hours.

Whatsapp:+852 6736 4057
Telegram:@hinovopept
Email:novopept@gmail.com

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