Afoxolaner CAS Number: 1093861-60-9

Afoxolaner (CAS Number: 1093861-60-9) is a potent, orally administered insecticide and acaricide from the isoxazoline chemical class. It is widely recognized as the active ingredient in NexGard®, a leading dog flea and tick preventative.

Afoxolaner is increasingly available in generic forms and alternative brands worldwide, making it a versatile solution for pet owners and veterinary suppliers.

Looking to source Afoxolaner in bulk? Novopept supports wholesale orders with factory-direct pricing and reliable global logistics.

technical Data 

Chemical Name: Afoxolaner

CAS Number: 1093861-60-9

Molecular Formula: C₂₆H₁₇ClF₉N₃O₃

Molecular Weight: 625.88 g/mol

Appearance: White to off-white crystalline powder

Purity: ≥98% 

Solubility: Slightly soluble in water, soluble in DMSO, methanol, and ethanol

Melting Point: ~161–163 °C

Stability: Stable under normal storage conditions; avoid strong oxidizing agents

Storage Conditions:

Short-Term Storage: Store in a cool, dry, and dark place at 0–4 °C

Long-Term Storage: Store at −20 °C for extended stability

Afoxolaner targets the central nervous system of fleas and ticks to effectively eliminate infestations.

• Selective Inhibition: Acts as an antagonist at GABA-gated chloride channels in parasites.
• Hyper-excitation: Blocks chloride ion transfer across cell membranes, causing uncontrolled nerve activity in the parasite.
• Rapid Parasite Death: Results in paralysis and death of fleas and ticks while remaining safe for dogs at recommended doses.

Afoxolaner is primarily used to treat and prevent flea (Ctenocephalides felis) and tick infestations, including:

• American dog tick
• Black-legged tick (Deer tick)
• Brown dog tick

Key Benefits:

• FDA-approved and safe for dogs when used as directed
• Available as generic afoxolaner for global markets

Afoxolaner is highly safe for dogs, but some may experience mild side effects:

• Vomiting, diarrhea
• Lethargy
• Dry or flaky skin
• Loss of appetite

Neurological Caution:

• Isoxazoline class drugs may rarely cause muscle tremors, ataxia, or seizures
• Use with caution in dogs with a history of seizures

 

Q: Is afoxolaner the same as ivermectin?

No. Ivermectin targets internal parasites like heartworms, while afoxolaner targets external fleas and ticks.

Q: Can humans take afoxolaner?

Currently not approved for humans, though research is exploring potential vector control applications.

Q: How is afoxolaner different from NexGard®?

NexGard® is the most recognized brand containing afoxolaner. Generic alternatives are increasingly available.

Message us to get your personalized quotation within 24 hours.

• Whatsapp:+852 6736 4057

• Telegram:@hinovopept

• Email:novopept@gmail.com

Hot Tags: afoxolaner cas number: 1093861-60-9, China afoxolaner cas number: 1093861-60-9 manufacturers, suppliers, factory