Melanotan II CAS 121062-08-6
Melanotan II (CAS 121062-08-6) is a synthetic analog of the naturally occurring α-MSH (alpha-melanocyte-stimulating hormone). It stimulates melanogenesis, the process responsible for melanin production in the skin. Originally developed for research, Melanotan II has gained cosmetic attention for enhancing tanning, supporting UV protection, and promoting a radiant, youthful look.
what's Melanotan II (CAS 121062-08-6)?
Melanotan II is a synthetic cyclic peptide and a non-selective melanocortin receptor agonist. It is structurally derived from α-melanocyte-stimulating hormone (α-MSH) and is widely studied for its effects on melanogenesis, pigmentation signaling pathways, and melanocortin receptor activation. Due to its unique receptor profile, Melanotan II has become a reference compound in pigmentation research, photobiology, and melanocortin system studies.
Novopept is a reliable Melanotan II factory and professional supplier of Melanotan II (CAS No. 121062-08-6) raw powder. We specialize in high-purity peptide production, offering Melanotan II with a purity of up to 99%, supported by a Certificate of Analysis (COA) for every batch.
For buyers searching for Melanotan II for sale, we provide stable supply capacity and consistent quality, ensuring your procurement process is efficient and risk-controlled.
Technical Specification
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| Item | Specification |
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| Chemical Name | Melanotan II |
| CAS Number | 121062-08-6 |
| Molecular Formula | C50H69N15O9 |
| Molecular Weight | ~1024.18 g/mol |
| Peptide Type | Cyclic synthetic peptide |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥98% (HPLC) |
| Solubility | Soluble in water |
| Storage | −20 °C recommended, protected from light |
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key benefits
Potent Melanocortin Receptor Activation
Melanotan II is a strong agonist of melanocortin receptors (MC1R–MC5R), making it highly valuable for studying receptor-mediated signaling pathways.
Enhanced Melanogenesis Research Value
By activating MC1R, Melanotan II significantly stimulates melanin production pathways, serving as a key reference compound in pigmentation and melanocyte biology research.
Non-Selective Receptor Profile
Unlike more selective analogs, Melanotan II interacts with multiple melanocortin receptors, enabling broader investigation into pigmentation, metabolic, and neuroendocrine mechanisms.
Improved Stability vs. Natural Peptides
Its cyclic peptide structure offers higher stability and longer biological activity compared to endogenous α-MSH, making it suitable for controlled experimental studies.
Widely Cited Research Peptide
Melanotan II is extensively referenced in scientific literature related to photobiology, pigmentation disorders, and melanocortin system modeling.
Supports Comparative Peptide Studies
Commonly used as a benchmark compound in comparisons with Melanotan I, α-MSH, and other melanocortin analogs.
Mechanism of Action
Melanotan II binds to melanocortin receptors, particularly MC1R, triggering the adenylate cyclase–cAMP pathway. This signaling cascade enhances transcription of melanogenic enzymes, promoting melanin synthesis within melanocytes. Its non-selective receptor profile also allows researchers to study downstream effects associated with MC3R and MC4R signaling pathways.
Applications of Melanotan II
Pigmentation Research
Used to study melanin production and the regulation of melanocytes, helping in the development of treatments for pigmentation disorders like vitiligo and melasma.
Melanocortin Receptor Studies
Investigates the activation of melanocortin receptors (MC1R–MC5R), aiding research in pigmentation, metabolic regulation, and neuroendocrine signaling.
UV-Response and Photobiology
Studies the body's photoprotective response to UV radiation by simulating melanin production and skin pigmentation.
Metabolic and Appetite Regulation
Explores the role of melanocortin signaling in energy balance, obesity, and appetite control.
Comparative Peptide Research
Used to compare with other melanocortin analogs (e.g., Melanotan I, α-MSH) to better understand receptor-specific effects.
Pigmentation Disorder Models
Helps create models for hyperpigmentation and hypopigmentation, supporting potential therapies.
Cellular and Molecular Studies
Applied in in vitro studies to observe melanocyte behavior and molecular pathways related to pigmentation.
Melanotan II vs Melanotan I vs. α-MSH
| Feature | Melanotan II | Melanotan I (Afamelanotide) | α-MSH |
|---|---|---|---|
| Receptor Selectivity | Non-selective (MC1R–MC5R) | Primarily MC1R | Natural ligand |
| Stability | High | Very high | Low |
| Research Focus | Broad melanocortin signaling | Pigmentation specificity | Physiological baseline |
| Structure | Cyclic | Linear | Linear |
Melanotan II is a non-selective melanocortin receptor agonist that activates MC1R–MC5R, promoting melanin production and influencing a range of physiological processes like pigmentation and metabolism.
Melanotan I (Afamelanotide) is more selective for MC1R, primarily used for skin pigmentation in conditions like erythropoietic protoporphyria, and has higher stability than Melanotan II.
α-Melanocyte-Stimulating Hormone (α-MSH) is the natural ligand for MC1R, playing a role in pigmentation and appetite regulation. However, it has low stability compared to synthetic analogs like Melanotan I and II.
FAQ
What is Melanotan II mainly used for in research?
It is primarily used to study melanocortin receptor signaling, melanogenesis, and pigmentation-related biological pathways.
How is Melanotan II different from Melanotan I?
Melanotan II is non-selective across melanocortin receptors, while Melanotan I is more selective for MC1R.
Is Melanotan II a natural peptide?
No. It is a synthetic analog inspired by α-MSH but modified for stability and receptor activity.
Is this product intended for cosmetic or medical use?
No. It is supplied strictly for research and laboratory purposes.
Why buy bulk Melanotan II from novopept with factory price?
- High-Purity Melanotan II Manufacturing (≥98%)
- Strict QC: HPLC & MS Verification
- Consistent Batch-to-Batch Quality
- Experienced Peptide Supply Chain
- Global Research Supply Support
certifications
Shipping methods
| Country | Delivery time |
| Untied states | 7-15 DAYS |
| Australia | 7-12 DAYS |
| Germany | 7-12 DAYS |
| Canada | 8-10 DAYS |
| New zealand | 7-10 DAYS |
| Uk | 5-10 DAYS |
| Thailand | 5-8 DAYS |
| Malaysia | 5-8 DAYS |
| Vietnam | 5-8 DAYS |
The delivery time shown above is an estimate. Shipping routes and freight capacity may change from time to time. For the most accurate delivery schedule, please contact us directly.
Payment terms
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