Ozenoxacin CAS 245765-41-7
What Is Ozenoxacin ? Ozenoxacin is a novel, non-fluorinated quinolone antibiotic API developed exclusively for topical dermatological applications . Unlike traditional fluoroquinolones, Ozenoxacin does not contain a fluorine atom , resulting in an improved safety profile and negligible systemic...
What Is Ozenoxacin?
Ozenoxacin is a novel, non-fluorinated quinolone antibiotic API developed exclusively for topical dermatological applications. Unlike traditional fluoroquinolones, Ozenoxacin does not contain a fluorine atom, resulting in an improved safety profile and negligible systemic absorption.
As a professional Ozenoxacin API manufacturer and supplier, we provide ≥99.0% purity pharmaceutical-grade Ozenoxacin suitable for the development of topical creams, ointments, and dermatological formulations. Full regulatory documentation (COA, MSDS, DMF upon request) is available to support global registrations.
API Category: Topical Antibiotics
Dosage Form Compatibility: Creams, ointments, gels
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Item |
Specification |
|
Product Name |
Ozenoxacin |
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CAS Number |
245765-41-7 |
|
Chemical Name |
1-cyclopropyl-8-methyl-7-(5-methylpyridin-3-yl)-4-oxoquinoline-3-carboxylic acid |
|
Molecular Formula |
C₂₁H₂₁N₃O₃ |
|
Molecular Weight |
363.42 g/mol |
|
Appearance |
Crystalline powder |
|
Purity (HPLC) |
≥99.0% |
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Quality Standard |
In-house / GMP |
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Documentation |
COA, MSDS, DMF available |
Key Advantages of Ozenoxacin
- Non-fluorinated quinolone with enhanced safety profile
- High potency against Gram-positive pathogens, including MRSA
- Negligible systemic absorption, ideal for topical use
- Low resistance potential compared with older topical antibiotics
- Short treatment duration, improving patient compliance
Mechanism of Action (MOA)
Ozenoxacin exhibits rapid bactericidal activity through a unique dual-target mechanism, setting it apart from traditional topical antibiotics.
How Ozenoxacin Works:
Dual Enzyme Inhibition: Simultaneously inhibits DNA gyrase and topoisomerase IV, both essential for bacterial DNA replication and repair
Resistance Avoidance: Effectively bypasses common bacterial efflux pumps that limit the efficacy of other quinolones
High Bactericidal Potency: Demonstrates strong activity against Staphylococcus aureus, Streptococcus pyogenes, and MRSA
What Is Ozenoxacin Used For?
The primary clinical indication for Ozenoxacin is the treatment of impetigo, a highly contagious superficial bacterial skin infection.
Clinical Applications:
- Indication: Impetigo
- Target Pathogens:
- Staphylococcus aureus
- Streptococcus pyogenes
- Patient Population: Approved for adults and pediatric patients ≥2 months old
- Topical Safety: Remains localized in the epidermis and stratum corneum, minimizing systemic exposure
What Are the Common Side Effects of Ozenoxacin?
Ozenoxacin is generally well tolerated. Reported side effects are localized and mild, including:
- Application-site irritation or erythema
- Rare cases of seborrheic dermatitis or rosacea
Due to minimal systemic absorption, systemic adverse effects such as nausea or dizziness are uncommon.
Ozenoxacin vs. Mupirocin
While Mupirocin has long been considered a standard topical antibiotic, Ozenoxacin represents a next-generation alternative with several clinical and technical advantages.
| Feature | Ozenoxacin API | Mupirocin |
|---|---|---|
| Drug Class | Non-fluorinated quinolone | Pseudomonic acid derivative |
| Mechanism | DNA gyrase & Topo IV inhibition | Protein synthesis inhibition |
| Speed of Action | Rapid (clinical response often within 2 days) | Moderate |
| Treatment Duration | 5 days (2× daily) | 7–10 days (3× daily) |
| MRSA Activity | High potency | Effective but resistance increasing |
| Resistance Risk | Low | Increasing globally |
| Systemic Absorption | Negligible | Minimal but higher than Ozenoxacin |
| Patient Compliance | High | Moderate |
Conclusion :
Ozenoxacin offers superior compliance, potency, and resistance control, making it a premium choice for modern topical antibiotic formulations.
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Email:novopept@gmail.com
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