Mavacamten CAS 1642288-47-8
Mavacamten (CAS 1642288 47 8) is a transformative, targeted therapy for obstructive HCM. With a unique MOA, established FDA approval, and strong patient interest globally, it continues to reshape cardiomyopathy treatment. Patient reported discussions emphasize life quality improvements, monitoring logistics, and cost, giving you insight into both clinical and end user priorities that matter most.
What Is Mavacamten?
Mavacamten CAS 1642288-47-8 is a novel small molecule cardiac myosin inhibitor developed for the treatment of symptomatic obstructive hypertrophic cardiomyopathy (oHCM). It is marketed under the brand name Camzyos® and represents the first approved therapy targeting the underlying sarcomere hypercontractility that drives this disease.
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Name |
Mavacamten |
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Synonyms/Code |
MYK-461, SAR439152 |
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CAS Number |
1642288-47-8 |
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IUPAC Name |
(S)-3-isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione |
|
Molecular Formula (MF) |
C15H19N3O2 |
|
Molecular Weight (MW) |
~273.34 g/mol |
|
Mechanism of Action |
Inhibits cardiac myosin, reducing the number of actin-myosin cross-bridges and decreasing the force of heart muscle contraction. |
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Purity |
≥98% |
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Physical Form |
White to off-white solid powder |
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Melting Point (MC) |
198–202°C |
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Solubility |
Soluble in DMSO and DMF |
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Storage (Long-Term) |
Powder should be stored at −20°C |
Mavacamten Mechanism of Action
Mavacamten mechanism of action focuses on selective modulation of cardiac muscle contraction. It binds to the beta cardiac myosin ATPase, stabilizing the myosin heads in a low activity "super relaxed" state. This reduces excessive actin myosin cross bridge formation, which:
Reduces hypercontractility
Improves diastolic relaxation
Lowers left ventricular outflow tract (LVOT) gradient
What Is Mavacamten Used For?
Mavacamten indications include the treatment of adult patients with symptomatic NYHA class II III obstructive hypertrophic cardiomyopathy to improve exercise capacity and symptoms of heart failure.
This approval marks a first in class breakthrough in cardiology, offering a targeted alternative to older therapy modalities.
Common Side Effects
Real world and clinical data indicate the following mavacamten side effects:
- Dizziness
- Fainting (syncope)
- Fatigue
- Headache
- Chest discomfort
- Palpitations
These align with user reported experiences on public forums, where fatigue and dizziness are frequently mentioned early in therapy.
Safety Considerations
Requires careful monitoring of ejection fraction (LVEF)
Potential for worsening systolic function or heart failure if not appropriately titrated
Mavacamten Price
While market pricing varies significantly by region, payer, and insurance coverage, historical pricing data cited in patient communities suggest:
Wholesale acquisition cost per capsule: approx. $245
Estimated monthly cost: ~$7,300
Estimated annual cost: ~$89,000
Pricing transparency plays a significant role in purchase decisions and access discussions among patients and clinicians alike.
What People Are Discussing Online?
What Patients Care About
- Effectiveness Timeline: Many report improved symptoms from a few weeks to several months.
- Monitoring Burden: Frequent echocardiography and cardiology visits are a major concern
- Quality of Life: Users describe dramatic symptom reduction compared to prior therapies.
- Cost & Accessibility: Pricing and insurance coverage are common topics.
- Arrhythmia Questions: Some discuss arrhythmia risk and interactions with other cardiac meds.
These topics highlight real world priorities that shape search interest and decision making.
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