Ruxolitinib Phosphate CAS1092939-17-7

Ruxolitinib phosphate CAS No.: 1092939-17-7

What is Ruxolitinib Phosphate?

Ruxolitinib phosphate is the phosphate salt form of ruxolitinib - an orally active small-molecule inhibitor of Janus kinases JAK1 and JAK2. As the phosphate salt it is developed for oral tablet formulations and topical preparations (cream) and is supplied as a white to off-white powder for pharmaceutical manufacturing.

Property	Value
Name	Ruxolitinib phosphate (ruxolitinib as phosphate)
CAS No.	1092939-17-7.
Molecular formula (salt)	C₁₇H₂₁N₆O₄P (commonly reported) - MW ≈ 404.36 g·mol⁻¹ (phosphate salt). Free base MW ≈ 306.4 g·mol⁻¹.
Appearance	White to off-white powder.
Solubility	Highly soluble in water; pH-dependent; soluble in DMSO/EtOH; reported ≥8 mg/mL (water, warm/sonication).
Purity	Typically ≥98% HPLC
Storage	Refer to CoA; often stored at −20 °C for extended stability.

Mechanism of Action

Ruxolitinib competitively inhibits JAK1 and JAK2 tyrosine kinases, blocking downstream STAT signaling triggered by cytokines and growth factors. This reduces pathologic cytokine signaling and abnormal hematopoietic proliferation in myeloproliferative disorders. (Key clinical effect: reduction in splenomegaly, symptom control and modification of inflammatory signaling.)

What is uses of Ruxolitinib phosphate ?

Myelofibrosis (intermediate- or high-risk; primary, post-PV, post-ET).
Polycythemia vera (in adults intolerant of or resistant to hydroxyurea).
Acute and chronic steroid-refractory graft-versus-host disease (GVHD) in indicated age groups.

common side effects

Common reported: diarrhea, headache, dizziness, muscle spasms, peripheral edema (ankle/hand swelling).
Hematologic : dose-dependent reductions in hemoglobin and platelets (anemia, thrombocytopenia). Because of immunomodulation, increased risk of infections (including opportunistic infections-herpes zoster, tuberculosis reactivation, hepatitis B reactivation, fungal infections) has been reported. Close laboratory monitoring is required during therapy.

Patient-reported concerns (forums): weight gain and metabolic changes are frequently mentioned by patients in community discussions; patients also report infection concerns and the need for frequent blood monitoring.

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