
Acetyl Octapeptide-3 CAS 868844-74-0
Acetyl Octapeptide-3 (CAS 868844-74-0), often marketed as Snap-8, is a cutting-edge anti-aging peptide designed to mimic the effects of Botox® in a safe, topical form. It reduces muscle contraction at the skin level, softening expression lines and wrinkles — especially around the forehead, eyes, and mouth. With proven stability in cosmetic formulations, Acetyl Octapeptide-3 has become a star ingredient in premium serums and creams.
what's Acetyl Octapeptide-3?
Acetyl Octapeptide-3 (SNAP-8®) cas 868844-74-0 is a highly effective cosmetic peptide designed for anti-wrinkle and anti-aging skincare formulations. As an advanced derivative of Acetyl Hexapeptide-8, it provides enhanced modulation of facial muscle contractions, helping to reduce the depth and appearance of expression lines over time.
Widely used in serums, eye creams, and premium anti-aging formulations, Acetyl Octapeptide-3 is valued by cosmetic brands for its non-invasive, topical approach to wrinkle reduction.
Technical Specification
| Parameter | Specification |
|---|---|
| Appearance | White to off-white powder |
| Peptide Content | ≥ 98% (HPLC) |
| Water Solubility | Soluble in water |
| Molecular Formula | C₄₀H₇₂N₁₆O₁₄ |
| Molecular Weight | 904.1 g/mol |
| pH (1% solution) | 4.5 – 6.5 |
| Moisture Content | ≤ 5% |
| Loss on Drying | ≤ 5% |
| Heavy Metals (Pb, As, Hg, Cd) | ≤ 10 ppm |
| Microbial Limits | Total Plate Count ≤ 1000 CFU/gYeast & Mold ≤ 100 CFU/gE. coli: NegativeSalmonella: Negative |
| Storage | Store in a cool, dry place, away from light |
| Shelf Life | 24 months (unopened, at 2–8°C) |

Acetyl Octapeptide-3 benifits & Applications
Benefits
- Reduces dynamic expression wrinkles (forehead, crow's feet, frown lines)
- Enhances skin smoothness and youthful appearance
- Non-invasive, reversible alternative to injectable treatments
- Compatible with creams, serums, and eye-area products
- Supports synergistic multi-peptide anti-aging formulations
Acetyl Octapeptide-3 is used in:
- Anti-wrinkle serums and facial creams
- Eye creams and eye contour products
- Premium skincare formulations
Mechanism of Action
Acetyl Octapeptide-3 works by modulating the SNARE complex, which regulates neurotransmitter release at the neuromuscular junction. By partially inhibiting acetylcholine release, it reduces micro-muscle contractions beneath the skin. This leads to a visible relaxation of expression lines, providing a smoother skin surface without affecting natural facial expressions.
Acetyl Octapeptide-3
Side Effects
Common Side Effects
- Slight skin redness or irritation (rare)
- Temporary tingling or warming sensation
- Mild dryness or tightness in sensitive skin
Rare Side Effects
- Localized rash or itching
- Increased sensitivity in very reactive skin types
Safety Notes
- Effects are localized and reversible; no systemic absorption
- Non-invasive, unlike injectable wrinkle treatments
- Safe for daily cosmetic use at typical concentrations (0.002%–0.05%)

Comparison: Acetyl Octapeptide-3 vs Acetyl Hexapeptide-8 vs Pentapeptide-18
| Feature | Acetyl Octapeptide-3 (SNAP-8®) | Acetyl Hexapeptide-8 Argireline®) | Pentapeptide-18 (Leuphasyl®) |
|---|---|---|---|
| Peptide Length | Octapeptide | Hexapeptide | Pentapeptide |
| Primary Function | Reduces dynamic wrinkles | Reduces dynamic wrinkles | Muscle relaxation |
| Mechanism | SNARE complex modulation | SNARE complex inhibition | Neuromuscular signaling modulation |
| Application | Topical (creams, serums) | Topical | Topical |
| Onset | Gradual (2–4 weeks) | Gradual | Gradual |
| Suitable for Daily Use | Yes | Yes | Yes |
| Invasiveness | Non-invasive | Non-invasive | Non-invasive |
| Synergy | Often combined with Hexapeptides or Matrixyl® | Often combined with Octapeptides or Matrixyl® | Often combined with Hexapeptides |
FAQ - Acetyl Octapeptide-3 powder
Q: What is Acetyl Octapeptide-3 used for?
A: It is used in anti-aging skincare to reduce the appearance of expression lines by relaxing micro muscle contractions beneath the skin.
Q: Is Acetyl Octapeptide-3 the same as Argireline®?
A: No. Argireline® is Acetyl Hexapeptide-8 (hexapeptide), while Acetyl Octapeptide-3 (SNAP-8®) is an octapeptide with enhanced wrinkle-reducing potential.
Q: How is it applied?
A: Commonly used in creams, serums, and eye products at low concentrations (0.002%–0.05%) for optimal effect.
Q: Is it safe for daily use?
A: Yes. It is a topical cosmetic ingredient with a strong safety profile, mild, and reversible.
Q: Can it be combined with other peptides?
A: Yes. It is often used synergistically with Acetyl Hexapeptide-8, Matrixyl®, or other anti-aging peptides for multi-pathway benefits.
Where to find Chinese manufacture of Acetyl Octapeptide-3?
Choose novopept as your Acetyl Octapeptide-3 supplier.
- Premium Quality – Cosmetic-grade SNAP-8® with consistent purity, tested by HPLC for reliable performance in anti-aging formulations.
- Reliable Supply & Competitive Pricing – Flexible MOQs, stable production, and cost-efficient manufacturing from China.
- Professional Support – Full documentation (COA, SDS) and technical guidance for formulation, regulatory compliance, and global shipment.
certifications

Shipping methods

| Country | Delivery time |
| Untied states | 7-15 DAYS |
| Australia | 7-12 DAYS |
| Germany | 7-12 DAYS |
| Canada | 8-10 DAYS |
| New zealand | 7-10 DAYS |
| Uk | 5-10 DAYS |
| Thailand | 5-8 DAYS |
| Malaysia | 5-8 DAYS |
| Vietnam | 5-8 DAYS |
The delivery time shown above is an estimate. Shipping routes and freight capacity may change from time to time. For the most accurate delivery schedule, please contact us directly.
Payment terms

delivery records


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Conclusion & Disclaimer
Acetyl Octapeptide-3 (CAS 868844-74-0) is a premium skincare peptide that helps smooth wrinkles, relax facial tension, and deliver visible anti-aging results - without injections. Safe, effective, and versatile, it's a go-to ingredient in modern anti-aging skincare formulations.
⚠️ Disclaimer: This page is for cosmetic and educational purposes only. Acetyl Octapeptide-3 is not FDA-approved as a drug or injectable treatment.
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