
Estriol Powder CAS 50-27-1
Retinol (Vitamin A):Speeds cell turnover
GHK-Cu Peptide:Copper delivery, regenerative peptide
Hyaluronic Acid:Hydration & volume booster
what's Estriol Powder (CAS 50-27-1)?
Estriol (CAS 50-27-1) is a naturally occurring estrogenic hormone primarily produced during pregnancy. It plays a key role in the regulation of various bodily functions, especially in the reproductive system. As a potent but mild estrogen, Estriol is widely used in hormone replacement therapy (HRT), particularly for menopausal symptoms, as well as in other therapeutic applications for women's health.
| Property | Specification |
|---|---|
| Chemical Name | Estriol |
| CAS Number | 50-27-1 |
| Molecular Formula | C18H24O3 |
| Molecular Weight | 288.39 g/mol |
| Appearance | White to off-white powder |
| Purity | ≥ 98% |
| Solubility | Soluble in ethanol, acetone |
| Melting Point | 284-290°C |
| Storage | Store in a cool, dry place |

Estriol Benifits & Applications
Benefits
- Mild Estrogenic Effect: Ideal for women who require estrogen replacement without the stronger effects of estradiol or estrone.
- Bone Health Support: Estriol may help reduce the risk of osteoporosis by maintaining bone density.
- Urogenital Health: Helps alleviate symptoms of vaginal dryness and urinary tract issues during menopause.
Applications
- Hormone Replacement Therapy (HRT): Used to relieve symptoms of menopause, such as hot flashes, vaginal dryness, and osteoporosis prevention.
- Breast Health: Helps in the management of postmenopausal breast health.
- Skin and Anti-Aging Treatments: Estriol has mild effects on collagen production, making it useful in formulations aimed at improving skin elasticity and reducing wrinkles.
- Reproductive Health: It can be used for managing certain gynecological conditions, including vaginal atrophy.
Mechanism of Action
Estriol acts on estrogen receptors (ER) throughout the body, particularly in the uterus, breasts, and bone tissue. It has a mild estrogenic effect compared to other estrogens like estrone and estradiol. By binding to estrogen receptors, Estriol can regulate various physiological processes, including the promotion of cell proliferation and the modulation of gene expression related to female reproductive health.
Estriol Side Effects
Common side effects include:
- Breast Tenderness or Enlargement
Estrogenic hormones like Estriol can cause mild breast tenderness or enlargement, especially during the initial phase of use.
- Headaches or Migraines
Some women may experience headaches or migraines as a result of hormonal fluctuations caused by Estriol therapy.
- Mood Changes
Hormonal changes, including those induced by Estriol, can lead to mood swings, irritability, or anxiety in some individuals.
- Nausea or Vomiting
Estriol can sometimes cause nausea or mild gastrointestinal upset, especially in those who are sensitive to hormones.
- Fluid Retention
Some individuals may experience water retention or bloating, which is a known side effect of estrogen therapy.
- Vaginal Discharge
Estriol can increase vaginal secretions in some individuals, which may cause discomfort or require adjustment in dosage.
- Increased Risk of Blood Clots (Rare)
Although less common with Estriol than with stronger estrogens, prolonged use can increase the risk of blood clot formation. Regular monitoring is recommended.
- Skin Reactions
Some users may experience mild rashes or skin irritation, though this is less common with Estriol compared to other forms of estrogen.
Rare but Serious Side Effects
- Liver Damage: High doses or prolonged use may put strain on the liver, though this is rare.
- Increased Risk of Certain Cancers: Long-term estrogen use, including Estriol, may slightly increase the risk of certain types of cancers, such as breast cancer or endometrial cancer, although this risk is generally lower with Estriol compared to other stronger estrogens.
If you experience any unusual or severe side effects, it is crucial to consult a healthcare provider immediately.

Comparison: Estriol vs Estradiol vs Estrone
| Property | Estriol | Estradiol | Estrone |
|---|---|---|---|
| Potency | Mild | Strong | Moderate |
| Estrogenic Effect | Mild | Strong | Moderate |
| Used for Menopause | Yes | Yes | Yes |
| Used for Breast Health | Yes | Yes | Yes |
| Side Effects | Fewer | More | Moderate |
FAQ
1. What is Estriol used for?
Estriol is primarily used in hormone replacement therapy (HRT) to relieve symptoms of menopause and support women's reproductive health.
2. Is Estriol safe to use?
Yes, Estriol is considered safe for most women, especially when used in moderate doses for HRT or other therapeutic uses. It is gentler than other estrogens, reducing the risk of side effects.
3. Can I use Estriol for skin care?
Yes, Estriol can be used in skin care formulations for its collagen-boosting effects, promoting skin elasticity and helping to reduce wrinkles.
4. How should Estriol Powder be stored?
Estriol powder should be stored in a cool, dry place, away from direct sunlight and moisture.
5. Can Estriol be used in fertility treatments?
Estriol may be used in some fertility treatments, but it is important to consult with a healthcare provider for personalized guidance.
Why Choose us?
High Purity: Our Estriol Powder has a purity of ≥98%, ensuring superior quality and effectiveness.
Reliable Supply Chain: We provide consistent, high-quality estriol sourced from reputable manufacturers.
Expertise in Hormonal Products: With years of experience, we offer in-depth knowledge and support for your specific formulation needs.
Global Shipping: We offer worldwide shipping, ensuring that your orders are delivered in a timely manner.
certifications

Shipping methods

| Country | Delivery time |
| Untied states | 7-15 DAYS |
| Australia | 7-12 DAYS |
| Germany | 7-12 DAYS |
| Canada | 8-10 DAYS |
| New zealand | 7-10 DAYS |
| Uk | 5-10 DAYS |
| Thailand | 5-8 DAYS |
| Malaysia | 5-8 DAYS |
| Vietnam | 5-8 DAYS |
The delivery time shown above is an estimate. Shipping routes and freight capacity may change from time to time. For the most accurate delivery schedule, please contact us directly.
Payment terms

Conclusion & Disclaimer
Estriol Powder (CAS 50-27-1) is a promising cosmetic active for anti-aging skincare. It helps restore elasticity, reduce wrinkles, and enhance hydration, especially in post-menopausal skin. As the 'gentle estrogen', Estriol offers rejuvenating effects with a favorable safety profile.
⚠️ Disclaimer: This content is for cosmetic industry and educational purposes only. Estriol is not FDA-approved for systemic hormone therapy. Formulations must comply with local regulations.
Hot Tags: estriol powder cas 50-27-1, China estriol powder cas 50-27-1 manufacturers, suppliers, factory, cu peptide, Melanotan Ii Skincare, s acetyl l glutathion 200 mg, GHK Cu, coq10 100mg, glutacid l glutathione
Send Inquiry






