Reduced Glutathione GSH
L-Glutathione (reduced) is the bioactive form of glutathione — a tripeptide composed of glutamine, cysteine, and glycine — that functions as the body’s primary intracellular antioxidant. It plays a crucial role in detoxification, immune defense, and oxidative balance.
what's Reduced Glutathione (GSH) CAS 70-18-8?
Reduced Glutathione (GSH) is a naturally occurring tripeptide composed of three amino acids: glutamine, cysteine, and glycine. It plays a crucial role in maintaining cellular health by acting as a powerful antioxidant and detoxifier. GSH is vital in protecting the body from oxidative stress, supporting the immune system, and maintaining healthy liver function. Due to its ability to neutralize free radicals, GSH is widely recognized as a key molecule in anti-aging, detoxification, and overall wellness.
Technical Specification
| Parameter | Value |
|---|---|
| Chemical Name | Reduced Glutathione (GSH) |
| CAS Number | 70-18-8 |
| Molecular Formula | C10H17N3O6S |
| Molecular Weight | 307.33 g/mol |
| Purity | ≥ 98% (HPLC) |
| Appearance | White to off-white crystalline powder or solution |
| Solubility | Soluble in water and alcohol |
| Storage Conditions | Store in a cool, dry place, away from light |
| Shelf Life | 2 years when stored properly |
| Form | Oral capsules, intravenous, topical (for skincare) |
| Recommended Dosage | 250-500 mg per day (depending on individual needs) |
Benefits of Reduced Glutathione (GSH)
Powerful Antioxidant Protection
GSH neutralizes free radicals and reactive oxygen species (ROS), helping to protect cells from oxidative stress, which is a leading cause of aging and disease. This helps prevent cellular damage and promotes longevity.
Detoxification Support
GSH plays a key role in the liver detoxification process, by supporting phase II detoxification enzymes. It helps bind and neutralize toxins, ensuring efficient removal from the body.
Immune System Boost
GSH supports the immune system by enhancing the function of immune cells like T-cells and phagocytes. It helps to fight off infections and maintain immune health, especially during periods of stress or illness.
Skin Health and Anti-Aging
Due to its antioxidant properties, GSH helps reduce the appearance of wrinkles and skin aging. It is used in skin brightening products and is believed to inhibit the formation of melanin, leading to a more even skin tone.
Reduction of Inflammation
GSH helps reduce chronic inflammation by controlling the production of pro-inflammatory cytokines, supporting overall cellular health.
Improved Cellular Energy
As a crucial player in mitochondrial function, GSH helps improve the efficiency of cellular energy production by supporting the ATP production process, leading to better physical performance and stamina.
Applications of Reduced Glutathione (GSH)
- Anti-aging and Skincare: Used in topical formulations to reduce fine lines, wrinkles, and improve skin tone.
- Detoxification: Promoted in supplements aimed at liver detox and cleansing programs.
- Immune Health: Frequently found in supplements for boosting immune function and recovery from illness.
- Sports Nutrition: Taken to enhance endurance, muscle recovery, and reduce oxidative stress after exercise.
- Chronic Disease Management: Beneficial for conditions related to oxidative stress, such as Parkinson's, Alzheimer's, and cardiovascular diseases.
Comparison: Reduced Glutathione (GSH) vs. N-Acetyl Cysteine (NAC) vs. Alpha-Lipoic Acid (ALA)
| Feature | Reduced Glutathione (GSH) | N-Acetyl Cysteine (NAC) | Alpha-Lipoic Acid (ALA) |
|---|---|---|---|
| Mechanism of Action | Directly neutralizes free radicals, supports detoxification and immune function. | Precursor to glutathione, supports antioxidant defense and detox. | Powerful antioxidant; recycles other antioxidants like Vitamin C and E, supports mitochondrial function. |
| Antioxidant Activity | Directly combats oxidative stress by neutralizing ROS and free radicals. | Increases GSH levels, indirectly helps fight oxidative stress. | Antioxidant in both water and fat-soluble environments, regenerates other antioxidants. |
| Primary Role in Detoxification | Directly involved in liver detoxification, helps neutralize toxins. | Supports glutathione synthesis, enhances detoxification indirectly. | Supports detox by reducing oxidative damage to cells and tissues. |
| Skin Health | Helps brighten skin and reduce hyperpigmentation; reduces melanin production. | Not directly associated with skin health. | Supports skin health by reducing inflammation and oxidative stress. |
| Immune System Support | Boosts immune cell function, especially T-cells and macrophages. | Helps maintain healthy immune function by boosting GSH levels. | May support immune function via antioxidant activity, but not its primary role. |
| Side Effects | Mild side effects like headaches, nausea, or skin rash (rare). | Can cause gastrointestinal issues (nausea, diarrhea) in some people. | Mild side effects like headache, skin rash, or gastrointestinal discomfort. |
| Bioavailability | Best absorbed in reduced form; can be enhanced with liposomal delivery. | Well absorbed orally; bioavailability increases with liposomal form. | Easily absorbed; lipid-soluble, so effective in fat tissues. |
| Common Uses | Anti-aging, liver detox, skin brightening, immune system support. | Detoxification, respiratory health, antioxidant support. | Anti-aging, mitochondrial health, diabetes management, liver detox. |
side effects of Reduced Glutathione
Although Reduced Glutathione is generally considered safe, there may be mild side effects, especially when taken in high doses:
Mild Headaches
Gastrointestinal Distress: Bloating, nausea, or mild diarrhea may occur in some individuals.
Skin Rash: In rare cases, topical application may cause a skin rash or irritation.
Note: Side effects are rare and usually temporary. If you experience any severe reactions, consult a healthcare professional immediately.
FAQ
Q1: What is the difference between Reduced Glutathione (GSH) and other forms of glutathione?
Reduced Glutathione (GSH) is the active form that can directly neutralize free radicals and toxins in the body. Oxidized Glutathione (GSSG), on the other hand, is inactive and must be converted back to its reduced form to function effectively.
Q2: How should I take Reduced Glutathione for maximum benefits?
Oral supplements (250–500 mg per day) are common. Intravenous GSH is used for more immediate effects, while topical formulations are ideal for skin health and anti-aging.
Q3: Is Reduced Glutathione effective for detoxification?
Yes, GSH supports liver detoxification, especially in phase II, where toxins are bound and removed. It helps neutralize harmful substances and supports overall liver health.
Q4: Can Reduced Glutathione help with skin whitening?
Yes, due to its ability to reduce melanin production, GSH is often used in skin lightening products, helping to create a more even skin tone and reduce hyperpigmentation.
Q5: Are there any interactions with medications?
There are no common significant interactions, but always consult with a healthcare provider if you are on medication for conditions such as liver disease, autoimmune disorders, or cancer
certifications
Shipping methods
| Country | Delivery time |
| Untied states | 7-15 DAYS |
| Australia | 7-12 DAYS |
| Germany | 7-12 DAYS |
| Canada | 8-10 DAYS |
| New zealand | 7-10 DAYS |
| Uk | 5-10 DAYS |
| Thailand | 5-8 DAYS |
| Malaysia | 5-8 DAYS |
| Vietnam | 5-8 DAYS |
The delivery time shown above is an estimate. Shipping routes and freight capacity may change from time to time. For the most accurate delivery schedule, please contact us directly.
Payment terms
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