SNAP-8 Peptide
SNAP-8 is supplied as 10 mg lyophilized powder per vial, manufactured by Novopept a peptide factory in China. As an experienced China supplier, we provide SNAP-8 in sealed vials suitable for laboratory research and formulation development. For reconstitution, add 1 ml of bacteriostatic (BAC) water to each vial to fully dissolve the peptide, resulting in a 10 mg/ml solution.
what is Snap-8 (Acetyl Octapeptide-3) ?
SNAP-8 (Acetyl Octapeptide-3) cas 868844-74-0 is a next-generation cosmetic peptide designed for the reduction of expression lines through modulation of neuromuscular signaling. As an extended peptide derived from the SNARE-complex inhibition concept, SNAP-8® offers enhanced efficacy compared to traditional hexapeptides, making it a preferred active ingredient for high-performance anti-aging formulations.
Technical Data
| Item | Specification |
|---|---|
| INCI Name | Acetyl Octapeptide-3 |
| SNAP-8 CAS No. | 868844-74-0 |
| Molecular Formula | C₄₁H₇₀N₁₆O₁₆ |
| Molecular Weight | ~951.1 Da |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water |
| Recommended Use Level | 0.01% – 0.05% |
| Application Phase | Water phase |
| Storage | 2–8 °C, protected from light and moisture |
| Shelf Life | 24 months (sealed, refrigerated) |
Mechanism of Action of Snap-8
Step 1 – Neuromuscular Signal Modulation
After topical application, SNAP-8® (Acetyl Octapeptide-3) interacts with proteins involved in neuromuscular signal transmission at the skin surface.
Step 2 – SNARE Complex Inhibition
SNAP-8® partially interferes with SNARE complex assembly, reducing the release of neurotransmitters responsible for facial muscle contraction.
Step 3 – Expression Line Softening
Lower muscle contraction intensity reduces repetitive mechanical stress on the skin, resulting in a visible smoothing of expression lines with continuous use.
Acetyl Octapeptide-3 Applications
SNAP-8® is widely used in functional and premium cosmetic products targeting dynamic wrinkles and expression lines:
- Anti-wrinkle and anti-aging creams
- Facial and eye serums
- Eye contour and crow's feet treatments
- Firming and lifting skincare products
- Professional / cosmeceutical formulations
It is particularly suitable for products positioned as "Botox-like" non-injectable skincare solutions.
DIY Snap-8 (Acetyl Octapeptide-3) - How People Do It
1. Reconstitution
Snap-8 comes as 10 mg lyophilized powder vials.
add 1 ml bacteriostatic (BAC) water to dissolve.
Result = 10 mg/ml solution.
2. Dilution into skincare base
Common method: mix the reconstituted Snap-8 into a serum or cream base .
Example discussed in r/Peptidesource
Add 10 mg (1 ml of reconstituted Snap-8) into 30 ml serum base → ~0.03% concentration.
Some aim higher (e.g., 10–20 mg in 30 ml), but users caution you can't remove peptide once added.
Combining with other actives
Many DIY users add Snap-8 alongside:
- GHK-Cu peptide (skin regeneration)
- Hyaluronic acid (hydration, carrier)
- Niacinamide or Vitamin C (brightening)
They stress pH matters - peptides work best in neutral to slightly acidic formulations.
Cautions :
- Stability: Snap-8 is a peptide - it can degrade if not stored properly (fridge storage recommended).
- Preservatives: DIY mixes often lack preservatives → risk of contamination if kept too long.
- Dosing: No clear consensus on "right %" - many cite 0.05%–0.1% in finished product as typical in cosmetic studies.
- Effect: Works best as a supportive anti-wrinkle ingredient, not a replacement for Botox.
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