ACETYL HEXAPEPTIDE-8 Cas 616204-22-9
Acetyl Hexapeptide-8, widely known as Argireline®, is a clinically proven biomimetic peptide used in high-end anti-aging skincare formulations. It is recognized as a safe and gentle alternative to Botox-like wrinkle reduction, helping visibly smooth forehead lines, crow’s feet, and expression wrinkles for a smoother, younger-looking appearance.
what's Acetyl Hexapeptide-8 CAS Number: 616204-22-9?
Acetyl Hexapeptide-8 is a well-known cosmetic peptide widely used in anti-aging and anti-wrinkle skincare formulations. It is designed to reduce the appearance of dynamic facial wrinkles by modulating neuromuscular communication, offering a non-invasive, topical alternative to injectable anti-wrinkle treatments.
As a highly stable and water-soluble peptide, Acetyl Hexapeptide-8 is commonly incorporated into serums, creams, eye care products, and advanced cosmeceutical formulations targeting expression lines such as forehead wrinkles, crow's feet, and nasolabial folds.
Technical Specification
|
Item |
Details |
|
Product |
Acetyl Hexapeptide-8 |
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CAS Number |
616204-22-9 |
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Purity |
≥ 98% (HPLC) |
|
Appearance |
White to off-white powder |
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Solubility |
Water-soluble |
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Molecular Type |
Biomimetic neuropeptide |
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Grade |
Cosmetic grade |
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Storage |
-20°C sealed; protect from light |
Argireline benifits & Applications
Benefits
- Visibly reduces expression lines and dynamic wrinkles
- Helps relax facial muscle micro-contractions
- Improves skin smoothness and youthful appearance
- Non-invasive alternative to injectable wrinkle treatments
- Suitable for long-term cosmetic use
Applications
Acetyl Hexapeptide-8 is widely applied in:
- Anti-wrinkle and anti-aging facial serums
- Eye creams and eye contour products
- Facial creams and lotions
- Professional cosmeceutical formulations
- Premium skincare products targeting expression lines
Argireline Mechanism of Action
Acetyl Hexapeptide-8 works by inhibiting the formation of the SNARE complex, which is responsible for neurotransmitter release at the neuromuscular junction.
By partially blocking the release of acetylcholine, the peptide reduces excessive muscle contraction beneath the skin. This leads to a visible relaxation of facial muscles and a subsequent reduction in the depth and appearance of expression wrinkles over time, without affecting overall facial mobility.
Argireline Side Effects
Common Side Effects
- Mild skin irritation or redness
- Slight tingling or warming sensation upon application
- Temporary dryness or tightness
- Mild itching in sensitive skin types
Rare Side Effects
- Localized swelling or discomfort
- Increased skin sensitivity
- Mild rash or contact dermatitis
Safety Profile
- Non-toxic and non-invasive
- No muscle paralysis; does not enter systemic circulation
- Effects are localized and fully reversible
- Suitable for long-term cosmetic use
Comparison: Acetyl Hexapeptide-8 vs. Other Anti-Aging Actives
| Feature | Acetyl Hexapeptide-8 | Botulinum Toxin (Botox®) | Pentapeptide-18 (Leuphasyl®) | Palmitoyl Peptides (Matrixyl®) |
|---|---|---|---|---|
| Ingredient Type | Cosmetic peptide | Medical neurotoxin | Cosmetic peptide | Cosmetic signaling peptides |
| Application Method | Topical (cream, serum) | Injectable | Topical | Topical |
| Primary Function | Reduces expression wrinkles | Muscle paralysis | Muscle relaxation | Collagen & ECM stimulation |
| Mechanism of Action | Inhibits SNARE complex formation | Blocks acetylcholine release | Modulates neuromuscular signaling | Activates fibroblasts |
| Invasiveness | Non-invasive | Invasive medical procedure | Non-invasive | Non-invasive |
| Onset of Effect | Gradual (2–4 weeks) | Rapid (days) | Gradual | Gradual |
| Reversibility | Fully reversible | Temporary but medical | Fully reversible | Fully reversible |
| Suitable for Daily Use | Yes | No | Yes | Yes |
| Regulatory Status | Cosmetic ingredient | Prescription medical product | Cosmetic ingredient | Cosmetic ingredient |
| Typical Use Level | 0.005–0.05% | N/A | 0.01–0.05% | 2–5% |
Compared with injectable anti-wrinkle treatments, Acetyl Hexapeptide-8 offers a safe, non-invasive cosmetic solution for reducing dynamic facial wrinkles. Unlike collagen-stimulating peptides such as Matrixyl®, it specifically targets neuromuscular signaling, making it ideal for formulations focused on expression line relaxation rather than structural skin remodeling.
FAQ - Acetyl Hexapeptide-8
What does Acetyl Hexapeptide-8 do?
Acetyl Hexapeptide-8 is a cosmetic peptide that helps reduce the appearance of expression wrinkles by relaxing micro muscle contractions beneath the skin. It works by modulating neuromuscular signaling, resulting in smoother-looking skin with regular topical use.
Is Acetyl Hexapeptide-8 the same as SNAP-8?
No. Acetyl Hexapeptide-8 and SNAP-8 are not the same. SNAP-8 (Acetyl Octapeptide-3) is a structurally extended peptide derived from Acetyl Hexapeptide-8 and is designed to offer enhanced wrinkle-reducing potential. They have different molecular structures and INCI names, although both are used for anti-wrinkle skincare.
Is Argireline® the same as Botox®?
No. Argireline® is a topical cosmetic ingredient, while Botox® is an injectable prescription neurotoxin. Argireline® does not paralyze muscles and does not require medical procedures. Its effects are milder, gradual, and fully reversible.
How does Argireline® work?
Argireline® inhibits the formation of the SNARE complex, reducing the release of acetylcholine at the neuromuscular junction. This decreases excessive muscle contraction beneath the skin, helping to minimize expression lines over time.
Is Argireline® safe for daily use?
Yes. When used at recommended cosmetic concentrations, Argireline® is considered safe for daily, long-term topical use and is well tolerated by most skin types.
Are there any side effects?
Side effects are rare and usually mild. Some users may experience temporary redness, tingling, or slight irritation, especially with sensitive skin. Performing a patch test before use is recommended.
What is the recommended usage level?
Typical use levels range from 0.005% to 0.05%, depending on formulation type and desired efficacy. It is effective at low concentrations, making it cost-efficient for formulations.
Can Argireline® be used with other active ingredients?
Yes. Argireline® is commonly combined with:
- Hyaluronic acid
- Niacinamide
- Antioxidants
- Collagen-stimulating peptides
Such combinations support multi-pathway anti-aging benefits.
Is Argireline® suitable for eye-area products?
Yes. When properly formulated, Argireline® is widely used in eye creams and eye serums targeting crow's feet and fine lines.
Is Argireline® approved for cosmetic use?
Argireline® is globally recognized as a cosmetic ingredient and is widely used in skincare products across major international markets.
Is Argireline® suitable for all skin types?
It is suitable for most skin types, including mature and sensitive skin. However, individuals with highly reactive skin should perform a patch test before regular use.
Why Choose novopept as your Acetyl Hexapeptide-8 supplier in china?
- Reliable Quality – Cosmetic-grade Acetyl Hexapeptide-8 with consistent purity and batch-to-batch stability.
- Competitive Supply – China-based manufacturing with flexible MOQ and cost-efficient pricing.
- Professional Support – Complete documentation (COA, SDS) and responsive technical service for global customers.
certifications
Shipping methods
| Country | Delivery time |
| Untied states | 7-15 DAYS |
| Australia | 7-12 DAYS |
| Germany | 7-12 DAYS |
| Canada | 8-10 DAYS |
| New zealand | 7-10 DAYS |
| Uk | 5-10 DAYS |
| Thailand | 5-8 DAYS |
| Malaysia | 5-8 DAYS |
| Vietnam | 5-8 DAYS |
The delivery time shown above is an estimate. Shipping routes and freight capacity may change from time to time. For the most accurate delivery schedule, please contact us directly.
Payment terms
delivery records
Message us to get your personalized quotation within 24 hours.
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Whatsapp:+852 6736 4057
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Telegram:@hinovopept
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Email:novopept@gmail.com
Conclusion
ACETYL HEXAPEPTIDE-8 offers a scientifically supported, non-invasive path to achieving smoother, more youthful-looking skin. By selectively targeting the mechanisms responsible for dynamic wrinkle formation, it provides a powerful, topically applied solution to combat the visible signs of aging.
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