1-Methylnicotinamide Chloride CAS No.: 1005-24-9

Name: China 1-Methylnicotinamide Chloride CAS No.: 1005-24-9 Manufacturers Suppliers Factory - NovoPept
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SKU: 288572478

What Is 1-Methylnicotinamide Chloride? 1-Methylnicotinamide chloride (1-MNA·Cl) is a methylated derivative of nicotinamide (vitamin B₃) formed endogenously in the liver through methylation of nicotinamide during nicotinamide adenine dinucleotide (NAD⁺) metabolism. It participates in...

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What Is 1-Methylnicotinamide Chloride?

1-Methylnicotinamide chloride (1-MNA·Cl) is a methylated derivative of nicotinamide (Vitamin B₃). In the body, it is formed endogenously in the liver through the methylation of nicotinamide during nicotinamide adenine dinucleotide (NAD⁺) metabolism. It plays a functional role in cellular salvage pathways and systemic metabolic regulation.

As a high-purity research-grade compound, 1-MNA·Cl is typically supplied as a stable, white to off-white crystalline powder. Its stability and solubility make it an ideal candidate for laboratory research, pilot studies, and advanced formulation development.

Novopept is a trusted supplier of 1-MNA·Cl, offering factory price advantages and stable bulk supply. High purity ≥98% and COA documentation ensure consistent quality.

Physical & Chemical Properties

CAS No.: 1005-24-9
Molecular Formula: C₇H₉N₂OCl

Appearance: white to off-white crystalline powder

Typical assay: ≥98.5% purity (HPLC)

Solubility: soluble in water and methanol

1-Methylnicotinamide chloride molecular structure

Mechanism of Action (MOA)

1-Methylnicotinamide chloride's primary role in research contexts includes:

Interaction with nicotinamide N-methyltransferase (NNMT) pathways, affecting methylation dynamics in the NAD⁺ salvage cycle.
Modulation of endothelial signaling pathways associated with prostacyclin and nitric oxide balance.
Participation in downstream regulatory events related to metabolic and oxidative processes.

Mechanism of Action of 1-Methylnicotinamide Chloride 1-MNA

Applications of 1-Methylnicotinamide Chloride

1-MNA has been examined within preclinical research for:

Endothelial function and vascular signaling, where it exhibits anti-thrombotic activity mediated via prostacyclin pathways.
Exercise capacity and metabolic modulation, with impacts on insulin sensitivity in diabetic mouse models.
Metabolic regulation downstream of NAD⁺ salvage pathways, including effects on methylation homeostasis.

Note: These findings emerge primarily from laboratory and animal studies, and 1-MNA's relevance in human physiology is subject to ongoing scientific investigation.

In beauty-focused research frameworks, mitochondrial efficiency is increasingly viewed as an upstream factor influencing body composition and cellular vitality.

Comparison with NAD⁺ Precursors

1-Methylnicotinamide Chloride (1-MNA) vs. Nicotinamide Riboside (NR)

1-MNA is a methylated metabolite formed downstream of nicotinamide metabolism; it does not directly serve as a precursor to NAD⁺.
NR is a riboside form that converts into NMN and subsequently contributes to intracellular NAD⁺ biosynthesis.

Research attention differs: 1-MNA is often studied for signaling roles, whereas NR is studied for elevating NAD⁺ pools in metabolic research.

1-Methylnicotinamide Chloride (1-MNA) vs. Nicotinamide Mononucleotide (NMN)

1-MNA does not enter the NAD⁺ salvage pathway as a direct NAD⁺ precursor.
NMN is an immediate precursor to NAD⁺ and is extensively researched for its role in mitochondrial function and energy metabolism.

Comparative research can help differentiate metabolic signaling roles (1-MNA) from NAD⁺ biosynthesis roles (NMN, NR).

1-MNA vs NR vs NMN Comparison Table

Attribute	1-Methylnicotinamide Chloride (1-MNA·Cl)	Nicotinamide Riboside (NR)	Nicotinamide Mononucleotide (NMN)
Chemical Class	Methylated nicotinamide metabolite	NAD⁺ precursor (riboside form)	NAD⁺ precursor (nucleotide form)
Relationship to NAD⁺	Downstream metabolite of NAD⁺ metabolism	Indirect precursor to NAD⁺ via NMN	Direct precursor to NAD⁺
Role in NAD⁺ Salvage Pathway	Does not re-enter NAD⁺ synthesis	Converted to NMN, then NAD⁺	Converted directly to NAD⁺
Primary Research Focus	Metabolic signaling, endothelial function, NNMT pathways	NAD⁺ restoration, mitochondrial function	Cellular energy metabolism, aging research
Key Enzymatic Association	Nicotinamide N-methyltransferase (NNMT)	NR kinases (NRK1/2)	NMN adenylyltransferases (NMNATs)
Mechanistic Orientation	Regulatory / signaling modulator	Biosynthetic intermediate	Biosynthetic intermediate
Typical Study Models	In vitro, animal metabolic and vascular models	Cellular, animal, human metabolic studies	Cellular, animal, translational aging studies
Bioavailability Research	Studied as endogenous metabolite	Actively studied for oral bioavailability	Actively studied for cellular uptake
Regulatory Status (General)	Evaluated as Novel Food ingredient (EU)	Dietary ingredient in multiple regions	Regulatory status varies by region
Research Positioning	Functional metabolite in NAD⁺ turnover	NAD⁺ pool enhancement research	NAD⁺ biosynthesis research
Common Comparative Context	Compared with NR/NMN for mechanism differentiation	Compared with NMN for efficiency	Compared with NR for uptake and conversion

Comparison of 1-MNA NR and NMN in NAD metabolism pathway

1-Methylnicotinamide Chloride Benefits

1. Supports Metabolic Signaling Pathways

1-MNA is an endogenous product of nicotinamide metabolism and plays a role in downstream regulation of NAD⁺ turnover, particularly in pathways involving NNMT activity and cellular methylation balance.

2. Endothelial Function and Vascular Research

Multiple preclinical studies associate 1-MNA with:

Prostacyclin-mediated endothelial signaling

Nitric oxide balance modulation

Anti-thrombotic activity in vascular models

These properties make 1-MNA relevant in cardiovascular and endothelial research frameworks.

3. Exercise and Energy Metabolism Research

Animal studies indicate that 1-MNA may influence:

Exercise tolerance

Skeletal muscle energy utilization

Metabolic efficiency under insulin-resistant conditions

This positions 1-MNA as a functional metabolite distinct from NAD⁺ precursors.

4. Differentiated from NAD⁺ Precursors

Unlike NR and NMN:

1-MNA does not increase intracellular NAD⁺ levels

Its value lies in signaling and regulatory roles, not NAD⁺ replenishment

This distinction is critical in comparative metabolic research and formulation strategy discussions.

5. Established Endogenous Presence

Because 1-MNA is naturally produced in the human body as part of vitamin B3 metabolism, it is often used in research to:

Study NAD⁺ flux and clearance

Explore methylation demand and metabolic trade-offs

Model downstream effects of sustained NAD⁺ precursor intake

6. Favorable Stability for Research Applications

As a chloride salt, 1-MNA·Cl exhibits:

Good chemical stability

High aqueous solubility

Suitability for controlled laboratory and formulation studie

Why Source Bulk 1-Methylnicotinamide from NovoPept Biotech

High Purity & Consistency: 1-Methylnicotinamide is produced with ≥99% purity (HPLC).

✅ Comprehensive Documentation: Full COA (Certificate of Analysis), MSDS, third-party lab reports (heavy metals, pesticides, residual solvents), and CAS verification.

✅ Scalable Supply: Bulk quantities(Monthly capacity of 500+ kg) available to support ongoing research programs and formulation development.

✅ Global B2B Support: Export-ready for qualified research partners worldwide.

✅ Competitive Bulk Pricing: Contact our sales team for quotes based on order volume (MOQ: 1kg).

1-Methylnicotinamide Chloride Certificate of Analysis from NovoPept Biotech

product-638-1097

Regulatory & Safety Notes

The European Food Safety Authority (EFSA) has evaluated 1-MNA as a novel food ingredient, concluding safety under proposed use levels with no evidence of genotoxicity, and noting the compound is a normal downstream metabolite of nicotinamide.

1-MNA is widely regarded as research material and not approved as a drug or dietary active ingredient in most regulatory jurisdictions.