S-Acetyl-Glutathione CAS 3054-47-5
S-Acetyl-Glutathione (CAS 3054-47-5) is a stabilized, acetylated form of glutathione designed to improve oral bioavailability and cellular delivery. It functions as a master antioxidant, detoxifier, and skin-protective molecule.
what's S-Acetyl-Glutathione CAS 3054-47-5?
S-Acetyl-Glutathione (SAG) is a stabilized, lipophilic derivative of reduced glutathione (GSH). By acetylating the sulfur group of glutathione, the molecule becomes significantly more resistant to oxidation and enzymatic degradation.
Unlike conventional glutathione, which is easily broken down in the gastrointestinal tract, S-Acetyl-Glutathione demonstrates enhanced stability and improved cellular uptake. Once inside the cell, the acetyl group is removed, releasing active glutathione where it is needed.
Technical Specification
| Parameter | Specification |
|---|---|
| Product Name | S-Acetyl-L-Glutathione |
| CAS Number | 3054-47-5 |
| Molecular Formula | C12H19N3O7S |
| Molecular Weight | 349.36 g/mol |
| Appearance | White to off-white crystalline powder |
| Identification | HPLC / IR Conforms |
| Assay (HPLC) | ≥ 98.0% |
| Solubility | Soluble in water |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.5% |
| Heavy Metals | ≤ 10 ppm |
| Lead (Pb) | ≤ 2 ppm |
| Arsenic (As) | ≤ 2 ppm |
| Cadmium (Cd) | ≤ 1 ppm |
| Mercury (Hg) | ≤ 0.1 ppm |
| Total Plate Count | ≤ 1,000 CFU/g |
| Yeast & Mold | ≤ 100 CFU/g |
| E. coli | Negative |
| Salmonella | Negative |
| Storage Condition | Store in a cool, dry place away from light |
| Shelf Life | 24 months under proper storage |
S-Acetyl-Glutathione
Benefits & Applications
Benefits
- Enhanced bioavailability compared to regular glutathione
- Increased intracellular glutathione levels
- Strong antioxidant support
- Supports liver detox pathways
- Promotes skin radiance and brightening
- Supports immune modulation
- Helps maintain mitochondrial integrity
Applications
Nutraceutical Industry
• Anti-aging capsules
• Antioxidant blends
• Liver support supplements
Cosmetic & Beauty Industry
• Oral skin brightening products
• Anti-pigmentation formulations
Research & Pharmaceutical
• Oxidative stress studies
• Neuroprotection research
• Detoxification pathway research
Mechanism of Action
- Cellular Uptake
The acetyl group increases membrane permeability, allowing the compound to cross cell membranes more effectively than standard glutathione.
- Intracellular De-acetylation
Once inside the cell, enzymatic processes remove the acetyl group, releasing active reduced glutathione (GSH).
- Redox Regulation
Restores intracellular GSH pools, supporting glutathione peroxidase and glutathione reductase systems.
- Detoxification Support
Participates in phase II conjugation reactions in the liver.
- Mitochondrial Protection
Reduces oxidative stress at the mitochondrial level.
S-Acetyl-Glutathione Side Effects
1. Gastrointestinal Effects (Most Common)
Mild nausea
Abdominal discomfort
Bloating
Diarrhea (rare, typically dose-related)
2. Detox-Related Reactions
Mild headache
Fatigue
Temporary skin breakouts
Flu-like symptoms
3. Allergic or Hypersensitivity Reactions (Rare)
Skin rash
Itching
Mild swelling
Individuals sensitive to sulfur-containing compounds should use caution.
4. Respiratory Concerns (Theoretical)
Inhaled glutathione has been associated with bronchospasm in individuals with asthma. This is not typically relevant for oral SAG, but caution is advised in sensitive populations.
Comparison: S-Acetyl-Glutathione vs Liposomal Glutathione
Delivery Method
SAG: Molecular modification
Liposomal GSH: Encapsulation system
Manufacturing Complexity
SAG: Standard powder handling
Liposomal GSH: Requires emulsification technology
Stability
SAG: High chemical stability
Liposomal GSH: Stability dependent on formulation quality
FAQ
Q1: Is S-Acetyl-Glutathione better than regular glutathione?
A: It generally demonstrates improved stability and cellular uptake due to acetyl protection.
Q2: Is it suitable for cosmetic formulations?
A: Yes, especially for advanced antioxidant and brightening formulations.
Q3: Is it stable in capsule form?
A: Yes, when stored in low-moisture environments.
Q4: What is the recommended purity for supplement use?
A: Typically ≥98% HPLC for high-quality nutraceutical applications.
Q5: Is this product for human consumption?
A: Availability depends on regulatory framework of the destination market. For research and formulation use only unless otherwise compliant.
Why Choose Us as your S-Acetyl-Glutathione Manufacturer or Supplier?
• GMP-compliant manufacturing
• ≥98% HPLC purity guarantee
• Third-party testing available
• Stable bulk supply capacity
• Competitive factory pricing
• COA, MSDS, and technical documentation provided
• Custom packaging & OEM support
• Global export experience
certifications
Shipping methods
| Country | Delivery time |
| Untied states | 7-15 DAYS |
| Australia | 7-12 DAYS |
| Germany | 7-12 DAYS |
| Canada | 8-10 DAYS |
| New zealand | 7-10 DAYS |
| Uk | 5-10 DAYS |
| Thailand | 5-8 DAYS |
| Malaysia | 5-8 DAYS |
| Vietnam | 5-8 DAYS |
The delivery time shown above is an estimate. Shipping routes and freight capacity may change from time to time. For the most accurate delivery schedule, please contact us directly.
Payment terms
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