Phenibut Powder CAS 1078-21-3
Phenibut (β-phenyl-GABA) is a synthetic derivative of the neurotransmitter GABA, discussed widely in online communities for its potential calming, mood-enhancing, and sleep-supporting effects. Originally developed in Russia, it is not FDA-approved in the USA or Canada and is controlled in several countries, but it remains a compound of interest in research related to anxiety management, sleep regulation, and social confidence.
what's Phenibut Powder CAS 1078-21-3 ?
Phenibut (β-phenyl-GABA) is a synthetic derivative of the neurotransmitter GABA, discussed widely in online communities for its potential calming, mood-enhancing, and sleep-supporting effects. Originally developed in Russia, it is not FDA-approved in the USA or Canada and is controlled in several countries, but it remains a compound of interest in research related to anxiety management, sleep regulation, and social confidence.
Technical Data
| Item | Specification |
|---|---|
| Product Name | Phenibut Powder |
| Chemical Name | β-Phenyl-γ-aminobutyric acid |
| CAS Number | 1078-21-3 |
| Molecular Formula | C10H13NO2 |
| Molecular Weight | 179.22 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥99% (HPLC) |
| Solubility | Soluble in water |
| Storage | Store in a cool, dry place, protected from light |
| Shelf Life | 24 months |
Phenibut Benefits & Applications
Anxiolytic research potential
Widely investigated for its calming and stress-reducing effects in CNS studies.
GABA-B receptor agonist activity
Primarily interacts with GABA-B receptors, supporting inhibitory neurotransmission research.
Enhanced CNS penetration
The phenyl substitution improves blood–brain barrier permeability compared with GABA.
High research relevance
Commonly used in neuroscience, behavioral studies, and pharmacological modeling.
Neuropharmacology research
Central nervous system (CNS) mechanism studies
GABA receptor pathway research
Behavioral and cognitive function studies
Reference material for analytical and formulation research
Phenibut Side Effects
Commonly Side Effects
- Drowsiness or sedation
- Dizziness or lightheadedness
- Fatigue
- Headache
- Nausea or gastrointestinal discomfort
Central Nervous System Effects
- Reduced alertness
- Impaired concentration or coordination
- Mood changes
Tolerance and Dependence Considerations
- Repeated or long-term exposure has been associated with tolerance development
- Abrupt discontinuation following extended use may lead to withdrawal-like symptoms in reported cases
Comparison: Phenibut vs GABA vs Baclofen
Comparison
| Aspect | Phenibut | GABA | Baclofen |
|---|---|---|---|
| Chemical Type | Synthetic GABA analog with phenyl group | Endogenous inhibitory neurotransmitter | Synthetic GABA derivative |
| Blood–Brain Barrier Penetration | High, due to phenyl ring | Very limited | High |
| Primary Receptor Activity | GABA-B receptor agonist | GABA-A and GABA-B (endogenous) | Selective GABA-B receptor agonist |
| CNS Availability | Effective in CNS research models | Poor when administered systemically | High and clinically established |
| Potency & Selectivity | Moderate, less selective | Physiological baseline | High potency and selectivity |
| Regulatory Status | Research compound | Endogenous molecule | Prescription pharmaceutical |
| Typical Use | Neuropharmacology and CNS research | Biochemical reference | Clinical treatment and medical research |
| Application Context | Laboratory and research use only | Physiological studies | Regulated medical settings |
This comparison is provided for scientific and informational purposes only.
Phenibut FAQ
1. How much should I take for anxiety vs. sleep?
• Anxiety: ~500 mg – 1.5 g
• Sleep: ~750 mg – 2 g in the evening (anecdotal, not medical advice).
2. How long does it take to work and how long does it last?
• Onset: 2–4 hours after oral intake
• Duration: 12–24 hours depending on metabolism.
3. Is there a risk of dependence?
• Yes. Tolerance develops quickly. Many limit use to 1–2 times per week. Withdrawal can be severe with frequent use.
4. Can I mix Phenibut with alcohol or sedatives?
• No. Combining with alcohol, benzodiazepines, or other CNS depressants is dangerous and may cause overdose.
5. What forms are available?
• Phenibut HCl: water-soluble, sour taste, most common.
• Phenibut FAA: less acidic, less soluble, sometimes preferred.
6. Is Phenibut legal in my country?
• USA: Not FDA-approved, gray area (sold as research chemical).
• Australia: Schedule 9, illegal.
• UK: Illegal under Psychoactive Substances Act.
• EU: Varies by country, often restricted.
• Canada: Not approved, sale prohibited.
Why Choose Us as Your Phenibut powder Supplier?
- Experienced China-based manufacturer
- Reliable synthesis and purification capabilities
- Competitive price
- Professional documentation and worldwide shipping
Shipping methods
| Country | Delivery time |
| Untied states | 7-15 DAYS |
| Australia | 7-12 DAYS |
| Germany | 7-12 DAYS |
| Canada | 8-10 DAYS |
| New zealand | 7-10 DAYS |
| Uk | 5-10 DAYS |
| Thailand | 5-8 DAYS |
| Malaysia | 5-8 DAYS |
| Vietnam | 5-8 DAYS |
The delivery time shown above is an estimate. Shipping routes and freight capacity may change from time to time. For the most accurate delivery schedule, please contact us directly.
Payment terms
delivery records
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