Expert review on reduced glutathione

Glutathione is a widely acting physiological factor, which is a tripeptide composed of glutamate, cysteine, and glycine. It is widely distributed in various organs of the body and plays an important role in maintaining cellular physiological functions. The active ingredient of this product is reduced glutathione, which can participate in the tricarboxylic acid cycle in the body, activate various enzymes, and have an inhibitory effect on the unstable thiol groups of eye lens proteins, thereby inhibiting the development of cataracts, suppressing corneal and retinal lesions, and promoting epithelial tissue repair in corneal damage. This product is clinically used to protect the liver. This medicine can inhibit the formation of fatty liver and improve the symptoms of toxic hepatitis and infectious hepatitis. This medicine also has detoxification function, which can combine with harmful substances such as electrophilic radicals and free radicals to produce detoxification and cell protection effects. Animal experiments have shown that glutathione can reduce renal dysfunction and neurotoxicity caused by cisplatin. The conclusions obtained from the four small-scale Phase II or III randomized clinical studies conducted using different dosing regimens are also different. Research has shown that glutathione has clinical significance in reducing the toxicity of chemotherapy drugs. However, appropriate scale studies targeting various types of tumors are still needed for validation. The optimal dosing regimen has not yet been determined, but further research is warranted by administering cisplatin for 30 minutes and glutathione 15 minutes before cisplatin administration, followed by intramuscular injection of the drug 72 hours later.