Desmopressin Acetate CAS 16679-58-6
Name：Desmopressin Acetate CAS Number: 16679-58-6 Molecular Formula: C46H64N14O12S2⋅C2H4O2 Molecular Weight: 1129.27 g/mol Appearance: White to off-white lyophilized powder Purity (HPLC): Greater than or equal to 98.0% Solubility: Highly soluble in water, physiological saline, and acetic acid.
Desmopressin Acetate | High Purity | Factory Direct Supplier
What is Desmopressin Acetate?
Desmopressin Acetate (CAS 16679-58-6) is a synthetic analogue of vasopressin (antidiuretic hormone, ADH), often referred to as the Desmopressin Acetate peptide in research contexts. It works by reducing urine production and increasing water reabsorption in the kidneys. Clinically, it has been used for diabetes insipidus, nocturnal enuresis (bedwetting), nocturia, and certain bleeding disorders (von Willebrand disease, hemophilia A).
Technical Specifications
| Item | Details |
| CAS Number | 16679-58-6 |
| Molecular Formula | C46H64N14O12S2⋅C2H4O2 |
| Molecular Weight | 1129.27 g/mol |
| Appearance | White to off-white lyophilized powder |
| Purity (HPLC) | $\ge 98.0\%$ |
| Solubility | Soluble in water and physiological saline |
Research & Applications
• Bedwetting / Nocturia:
Reduces nighttime urine production; many users report fewer accidents or awakenings.
• Diabetes Insipidus:
Provides ADH replacement to reduce excessive urination and thirst.
• POTS / Dysautonomia:
Helps some patients maintain hydration and blood pressure when standing.
• Hyponatremia Control (ICU Use):
Used in controlled hospital settings to stabilize sodium levels.
• Bleeding Disorders:
Occasionally used in von Willebrand disease and hemophilia A to increase clotting factor levels.
Desmopressin Acetate (DDAVP) – Mechanism of Action
Desmopressin acetate is a synthetic analogue of the natural antidiuretic hormone (ADH, also called vasopressin). It is designed to have enhanced antidiuretic activity with minimal vasopressor effect. Its mechanism can be summarized as follows:
1. Receptor Binding
Desmopressin selectively binds to V2 receptors located on the basolateral membrane of renal collecting duct cells in the kidney.
Unlike vasopressin, it has minimal activity at V1a receptors, which mediate vasoconstriction.
2. Intracellular Signaling
V2 receptor activation triggers Gs protein-mediated activation of adenylate cyclase.
This increases intracellular cyclic AMP (cAMP) levels.
3. Aquaporin-2 Recruitment
cAMP activates protein kinase A (PKA), which phosphorylates proteins that translocate aquaporin-2 (AQP2) water channels to the apical membrane of the collecting duct cells.
This allows water to be reabsorbed from the urine back into the bloodstream, concentrating the urine and expanding plasma volume.
Comparison - Desmopressin vs Fludrocortisone vs Midodrine
- Desmopressin acts primarily through antidiuresis and plasma volume expansion; evidence in orthostatic disorders is limited and its use is highly selective.
- Fludrocortisone increases sodium and water retention, providing chronic volume expansion but with notable long-term safety concerns.
- Midodrine induces peripheral vasoconstriction and has the strongest clinical evidence, making it a first-line pharmacologic therapy for neurogenic orthostatic hypotension.
|
Feature |
Desmopressin |
Fludrocortisone |
Midodrine |
|
Mechanism |
Synthetic ADH analogue, reduces urine output |
Mineralocorticoid, increases sodium & water retention |
Alpha-agonist, raises blood pressure via vasoconstriction |
|
Main Use |
Bedwetting, nocturia, DI, dysautonomia |
POTS, low BP, adrenal insufficiency |
POTS, orthostatic hypotension |
|
Key Risk |
Hyponatremia |
Low potassium, hypertension |
Supine hypertension, tingling |
|
Community Notes |
Good for short-term hydration control |
Better for chronic BP management |
Effective for upright BP but may cause jitters |
certifications
Shipping methods
| Country | Delivery time |
| Untied states | 7-15 DAYS |
| Australia | 7-12 DAYS |
| Germany | 7-12 DAYS |
| Canada | 8-10 DAYS |
| New zealand | 7-10 DAYS |
| Uk | 5-10 DAYS |
| Thailand | 5-8 DAYS |
| Malaysia | 5-8 DAYS |
| Vietnam | 5-8 DAYS |
The delivery time shown above is an estimate. Shipping routes and freight capacity may change from time to time. For the most accurate delivery schedule, please contact us directly.
Payment terms
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