BAM15 CAS 210302-17-3

BAM15, also known as CS-2890, is a synthetic small-molecule mitochondrial uncoupler that has been investigated in preclinical research for its role in regulating cellular energy expenditure. Unlike traditional metabolic modulators that influence appetite or hormonal signaling, BAM15 acts directly at the mitochondrial level, increasing energy dissipation through uncoupling oxidative phosphorylation.

Due to this unique mechanism, BAM15 has attracted scientific interest in the fields of metabolic research, weight management models, and mitochondrial biology, particularly in studies exploring energy balance and fat oxidation pathways.

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Technical info:

Chemical Name: BAM15

Synonym: CS-2890

CAS Number: 210302-17-3

Compound Class: Mitochondrial uncoupler

Molecular Type: Synthetic small molecule

Research Category: Energy metabolism & mitochondrial function

BAM15 is often grouped with next-generation mitochondrial uncouplers designed to enhance metabolic efficiency while minimizing systemic toxicity observed with earlier compounds.

BAM15 functions by uncoupling mitochondrial oxidative phosphorylation. Specifically, it facilitates proton transport across the inner mitochondrial membrane, reducing the efficiency of ATP synthesis. As a result:

• Cellular respiration increases
• Energy is dissipated as heat rather than stored as ATP
• Substrate oxidation (including fatty acids) is elevated

This mechanism leads to increased basal energy expenditure without directly interacting with central nervous system pathways or appetite regulation. From a research perspective, BAM15 is frequently studied as a tool compound to explore how mitochondrial uncoupling influences systemic metabolism.

Weight Management ：

• Energy expenditure modulation
• Fat oxidation pathways
• Body weight regulation models
• Metabolic flexibility studies

Beauty Science：

• Cellular energy balance
• Mitochondrial health and efficiency
• Metabolic support at the cellular level

In beauty-focused research, mitochondrial performance is increasingly recognized as a foundational element of overall metabolic health, which may indirectly influence body composition and skin vitality.

BAM15 is a next-generation mitochondrial uncoupler studied in preclinical research. It is often compared with other uncouplers such as DNP (2,4-Dinitrophenol).

BAM15: safer, targeted uncoupling in research models

DNP: potent but toxic, historical human use

For detailed comparisons, visit our BAM15 vs DNP & SLU-PP-332 article.

What does BAM15 do?

BAM15 is studied for its ability to increase mitochondrial energy expenditure by uncoupling oxidative phosphorylation, thereby promoting higher metabolic activity in preclinical models.

Is BAM15 used for weight loss?

BAM15 is investigated in research settings related to weight management and metabolic regulation. There is no approved or clinically validated use for weight loss in humans.

Is BAM15 FDA approved?

No. BAM15 has not been approved by the FDA or other regulatory authorities for human consumption or therapeutic use.

Is BAM15 safe to take?

Human safety data are not available. BAM15 should not be used outside of controlled research or formulation development environments.

What is the half-life of BAM15?

Precise human pharmacokinetic data are unavailable. Any half-life estimates are derived from experimental or animal studies and should be interpreted accordingly.

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